A total of 18 mtTFA SNPs specific to patients with AC with freque

A total of 18 mtTFA SNPs specific to patients with AC with frequencies >10% were identified. Two were located in the coding region and 16 were identified in non-coding regions. Conversely, there were five SNPs that were only Alvocidib cell line present in patients with AC and normal subjects and had a frequency >10%. In

the AC group, the hepatic mtTFA mRNA and protein levels were significantly lower than those in the other two groups. Moreover, the hepatic mtDNA copy number was significantly lower in the AC group than in the controls and alcoholics without AC. Based on these data, we conclude that AC-specific mtTFA SNPs may be responsible for the observed reductions in mtTFA mRNA, protein levels and mtDNA copy number and they may also increase the susceptibility to AC.”
“Almost all small animal SPECT is performed with pinhole collimators (PH), including single-PH (SPH) and multi-PH (MPH). In the clinical study, not only PH but also parallel-hole collimator (PAH) is often used in planar

and SPECT imaging. However, there have been no comparative studies on image quality with various collimators on the small animal imaging. This study compared the basic characteristics of PH and PAH in small animal imaging.\n\nPerformance of planar and SPECT images was evaluated using (TcO4)-Tc-99m (-) and SPH, MPH and PAH with low energy and high resolution on the SPECT/CT scanner FX3200. We measured sensitivity, resolution, concentration linearity and uniformity. Planar imaging of mice with Tc-99m-labeled mercaptoacetyltriglycine (Tc-99m-MAG(3)) was performed using SPH and PAH. SPECT imaging with Tc-99m-methylene diphosphonate Nirogacestat (Tc-99m-MDP) was performed using all collimators.\n\nWith SPH, MPH and PAH, sensitivity was 43.5, 211.2 and 926.5 cps/MBq, respectively, Dihydrotestosterone research buy and spatial resolution was 0.60/0.56, non/0.96, 5.20/5.34 mm full-width half maximum

(planar/SPECT), respectively. There were marked correlations between the radioactivity counts on images and radioactivity with all collimators. Values of % standard deviation on planar imaging showed small differences between the SPH and PAH, while the values were the smallest on SPECT imaging with MPH. On imaging of mice, SPH yielded high-quality Tc-99m-MAG(3)-planar images when compared with PAH. MPH yielded sharper Tc-99m-MDP-SPECT images than SPH and PAH.\n\nThe characteristics of PH and PAH differed on small animal imaging. Although sensitivity was higher with PAH, PH showed higher resolution. Among the PH collimators, SPH was more appropriate for planar imaging, and MPH was more suitable for SPECT imaging in a small animal imaging scanner with CZT detector.”
“Background: Depression has been found to be a predictor of rehospitalization and mortality in heart failure (HF). Parathyroid hormone (PTH) is a novel promising biomarker that can predict hospitalization, functional status and mortality in HF.

Five percent of analysed PC breeding boars had more than 20% admi

Five percent of analysed PC breeding boars had more than 20% admixture

of other monitored breeds. The obtained results are important for the future sustainability of this local breed.”
“Rationale Mast cells have important roles in innate immunity and tissue remodeling but have remained poorly studied in inflammatory Blebbistatin in vitro airway diseases like chronic obstructive pulmonary disease (COPD).\n\nObjectives: To perform a detailed histological characterization of human lung mast cell populations at different severities of COPD, comparing with smoking and never-smoking control subjects.\n\nMethods: Mast cells were analyzed in lung tissues from patients with mild to very severe COPD, GOLD I-IV (n = 25, 10 of

whom were treated with corticosteroids). Never-smokers and smokers served as controls. The density, morphology, and molecular characteristics of mucosal and connective tissue mast cells (MC(T) and MC(TC), respectively) were analyzed in several lung regions.\n\nMeasurements and Main Results: In all compartments PND-1186 price of COPD lungs, especially at severe stages, the MC(TC) population increased in density, whereas the MC(T) population decreased. The net result was a reduction in total mast cell density. This phenomenon was paralleled by increased numbers of luminal mast cells, whereas the numbers of terminal transferase dUTP nick end labeling (TUNEL)(+) apoptotic mast cells remained unchanged. In COPD lungs, the MC(T) and MC(TC) populations

showed alterations in morphology and expression of CD88 (C5a-R), transforming growth factor (TGF)-beta, and renin. Statistically significant correlations were found between several COPD-related mast cell alterations and lung function parameters.\n\nConclusions: selleck inhibitor As COPD progresses to its severe stages, the mast cell populations in the lung undergo changes in density, distribution, and molecular expression. In COPD lungs, these novel histopathological features were found to be correlated to lung function and they may thus have clinical consequences.”
“Melioidosis is a severe infectious disease caused by the saprophytic facultative intracellular pathogen Burkholderia pseudomallei. The disease is endemic in Southeast Asia and Northern Australia, and no effective vaccine exists. To describe human cell-mediated immune responses to B. pseudomallei and to identify candidate antigens for vaccine development, the ability of antigen-pulsed monocyte-derived dendritic cells (moDCs) to trigger autologous T-cell responses to B. pseudomallei and its products was tested. moDCs were prepared from healthy individuals exposed or not exposed to B. pseudomallei, based on serological evidence. These were pulsed with heat-killed B.

Here, we found that

active TB patients exhibited increase

Here, we found that

active TB patients exhibited increases in numbers of Tim-3-expressing CD4(+) and CD8(+) T cells, which preferentially displayed polarized effector memory phenotypes. Consistent with effector phenotypes, Tim-3(+)CD4(+) and Tim-3(+)CD8(+) T-cell subsets showed greater effector functions for producing Th1/Th22 cytokines and CTL effector molecules than Tim-3(-) counterparts, and Tim-3-expressing T cells more apparently limited intracellular Mtb replication in macrophages. The increased effector functions for Tim-3-expressing T cells Caspase-8 Inhibitor consisted with cellular activation signaling as Tim-3(+)CD4(+) and Tim-3(+)CD8(+) T-cell subsets expressed much higher levels of phosphorylated signaling molecules p38, stat3, stat5, and Erk1/2 than Tim-3-controls. Mechanistic experiments showed that siRNA silencing of Tim-3 or soluble Tim-3 treatment interfering with membrane Tim-3-ligand interaction reduced de novo production

of IFN-gamma and TNF-alpha by Tim-3-expressing T cells. Furthermore, stimulation of Tim-3 signaling pathways by antibody cross-linking of membrane Tim-3 Selleckchem Sotrastaurin augmented effector function of IFN-gamma production by CD4(+) and CD8(+) T cells, suggesting that Tim-3 signaling helped to drive stronger effector functions in active TB patients. This study therefore uncovered a previously unknown mechanism for T-cell immune responses regulated by Tim-3, and findings may have implications for potential immune intervention in TB.”
“Young seedlings of maritime pine (Pinus pinaster Soland in At.) were grown in rhizoboxes using intact spodosol soil samples from the southwest of France, in Landes of Gascogne, presenting a large variation of phosphorus (P) availability. Soils were collected from a 93-year-old unfertilized

stand and a 13-year-old P. pinaster stand with regular annual fertilization of either only P or P and nitrogen (N). After 6months of culture in controlled conditions, different morphotypes check details of ectomycorrhiza (ECM) were used for the measurements of acid phosphatase activity and molecular identification of fungal species using amplification of the ITS region. Total biomass, N and P contents were measured in roots and shoots of plants. Bicarbonate- and NaOH-available inorganic P (Pi), organic P (Po) and ergosterol concentrations were measured in bulk and rhizosphere soil. The results showed that bulk soil from the 93-year-old forest stand presented the highest Po levels, but relatively higher bicarbonate-extractable Pi levels compared to 13-year-old unfertilized stand. Fertilizers significantly increased the concentrations of inorganic P fractions in bulk soil. Ergosterol contents in rhizosphere soil were increased by fertilizer application. The dominant fungal species was Rhizopogon luteolus forming 66.6% of analysed ECM tips.

This has been shown to take the form U(s) = 1 58+2 47u(p) (rho(0)

This has been shown to take the form U(s) = 1.58+2.47u(p) (rho(0) = 0.945 g/cc) and comparison has been made between the dynamic behavior of the adipose material and both 20 wt % ballistic gelatin and water. The adipose material has been shown selleck kinase inhibitor to behave in likeness with simple polymers such as polyethylene and to strengthen under shock loading, unlike ballistic gelatin, which has been shown to behave hydrodynamically. An experimental

design incorporating direct insertion of lateral stress gauges within the rendered fat has given insight into both the behavior of lateral gauges and the lateral stress response of the material under dynamic loading. (C) 2010 American Institute of Physics. [doi:10.1063/1.3501046]“
“BACKGROUNDAceto Balsamico Tradizionale (ABT) is a typical Italian vinegar available in two different forms: Aceto Balsamico Tradizionale di Modena DOP (ABTM) and Aceto Balsamico Tradizionale

di Reggio Emilia DOP (ABTRE). ABT is obtained by alcoholic fermentation and acetic bio-oxidation of cooked grape must and aged at least 12years in wooden casks and is known and sold around the world. Despite this widespread recognition, data on sensory characteristics of these products are very scarce. Therefore a descriptive analysis was conducted to define a lexicon for the ABT sensory profile and to create https://www.selleckchem.com/products/LY2603618-IC-83.html a simple, stable and reproducible synthetic ABT for training panellists.\n\nRESULTSA lexicon of 20 sensory parameters was defined and validated and a synthetic ABT was prepared as standard reference. Simple standards for panellist training were also defined and the sensory profiles of ABTM and ABTRE were obtained.\n\nCONCLUSIONThe obtained results confirm that descriptive analysis can be used for the sensory characterisation of

ABT and that the sensory profiles of ABTM and ABTRE are very different. Furthermore, the results demonstrate that a lexicon and proper standard references are essential for describing the sensory selleck inhibitor qualities of ABT both for technical purposes and to protect the product from commercial fraud. (c) 2013 Society of Chemical Industry”
“Salvia, a hallucinogenic plant legally available in most of the United States, has become a widely discussed drug in the media. The extant research on Salvia use relies on non-probability samples and studies of college students. There is a clear need for research that identifies the correlates of Salvia use using data from a large sample that is nationally representative. The current study fills this important gap in the literature by using data from the 2009 National Survey on Drug Use and Health. This survey includes data from nearly 70,000 respondents ages 12 and older living in all 50 U.S. states and the District of Columbia. Due to survey design, separate analyses are conducted among adolescents and adults. Findings indicate that 1.

Objective The aim of this study was to determine the influenc

\n\nObjective The aim of this study was to determine the influence of neuroendocrine differentiation on treatment response and survival in patients with advanced NSCLC.\n\nMethods A clinical trial included 236 patients (73.7% males), with diagnosis

of NSCLC, determined by histological verification. These patients were treated by combined C188-9 concentration chemo- and X-ray therapy at stage III (without pleural effusion) or chemotherapy only at stage III (with pleural effusion) and stage IV of NSCLC. When the progression had been noted at the stage III (without pleural effusion), the treatment was continued with X-ray therapy. Neuron-specific enolase (NSE), chromogranin A (ChrA) as well as synapthophysin (SYN) expression in tissue examples was determined by immunohistochemical analysis with monoclonal mouse anti human bodies (DAKO Comp, Denmark). The treatment was conducted during 4 to 6 chemotherapeutic cycles. The efficacy was assessed after the therapy regimen; median survival time was assessed after the randomization.\n\nResults NSE, ChrA and SYN expression were noted in 56 (23.7%), 33 (13.9%) and 39(16.5%) patients, respectively. Better therapeutic response was significantly higher in patients with expression of NSE, ChrA and SYN (p<0.05). There was significant correlation between

therapy response and the percentage of positive tumour cells with neuroendocrine differentiation (p<0.05). The one-year and two-year follow-up

survival period in patients with neuroendocrine expression was 64% (without selleck products expression 28%; p<0.001) and 30% (p=0.000).\n\nConclusion Tissue expression of neuroendocrine markers influences greatly a therapeutic response in patients with advanced stage of NSCLC. Better therapeutic response was recorded in patients with possitive expression of neuroendocrine markers and higher percentage of positive tumour cells. Median survival time is higher in patients in III or IV stage of NSCLC, when neuroendocrine markers are expressed.”
“Background: Single-stage transanal endorectal pull-through (TEPT) is a new technique for surgery of Hirschsprung’s disease (HD). TEPT can be assisted by laparoscopy (laparoscopic assisted transanal pull-through, high throughput screening assay LATP) or with non-additional procedure (total transanal endorectal pull-through, TTEP). This study was undertaken to evaluate the long-term outcome of these approaches in children with HD.\n\nMethods: We retrospectively studied 131 patients (112 males and 19 females) aged 7 days to 14 years who underwent single-stage TEPT from October 2005. to July 2008. The medical records were reviewed for pre-, intraand immediate post-operative complications. The data on stool pattern and complications were collected during the follow-up. Outcome was measured by continence evaluation score.\n\nResults: No patients had intraoperative complications, but 5 had minor immediate postoperative complications.

Crown Copyright (C) 2009 Published by Elsevier B V All rights re

Crown Copyright (C) 2009 Published by Elsevier B.V. All rights reserved.”
“Spatial pattern and intensity of recruitment have substantial effects on adult community structure in some but not all marine systems. Such ‘supply-side’ effects have been relatively poorly studied in soft-sediment habitats because of the difficulty of sampling very small infaunal recruits. I investigated whether spatial patterns of infaunal recruitment along an estuarine gradient could account for the observed cline in adult diversity. On 9 occasions spread over 13 mo, cores of sterile sediment from 2 different sources

were embedded in beaches along the estuarine axis of Puget Sound, Washington, and sampled 6 wk later for new recruits. Identities and abundances of recruits (mostly polychaetes and bivalves) varied among seasons, but Akt inhibitor differed little between sediments from different sources. Contrary to expectations, neither recruit richness nor abundance was lower at the southern (more estuarine) end of the gradient, where adult taxonomic diversity is low. For a number of taxa and time periods, recruitment was actually stronger at the southern beaches. Multivariate differences between assemblages of recruits and adults were much greater at the southern sites, indicating

that post-recruitment processes at learn more these sites modify diversity and abundance patterns initially established by recruitment. These processes could include predation on juveniles, adult-juvenile competition, or physiologically stressful abiotic conditions.”
“AIM: To reinvestigate the accuracy of 16 section multidetector computed tomography (MDCT)

in assessing mandibular invasion in retromolar trigone (RMT) squamous cell cancers (SCC). MATERIALS AND METHODS: A search for diagnosed cases of early RMT SCC that were both imaged and treated at Tata Memorial Centre, Mumbai, India, between 2007 and 2010, was undertaken and yielded 37 patients. The average tumour size was 2.6 cm. All patients had undergone segmental, marginal, or hemimandibulectomy within 2 weeks of imaging. Imaging records archived on the picture archiving and communication https://www.selleckchem.com/products/selonsertib-gs-4997.html system (PACS) were analysed. Contrast-enhanced CT had been performed using a 16 section MDCT system using the puffedcheek technique. Image acquisition was at 2.5 mm section thickness, but axial images and isotropic coronal and sagittal multiplanar reformations were generated ad hoc from 0.625 mm retro-reconstructed images. Optimal oblique reformations were generated at will by the radiologist to depict the RMT in its entirety. The soft-tissue algorithm and bone window or bone algorithm reformations and axial images were analysed on a volume viewer integrated within the PACS using triangulation. Two investigators independently studied the images and these were compared with the findings at histopathology. RESULTS: The sensitivity, specificity, and accuracy of 16 section MDCT for mandibular cortical and marrow invasion was 94, 90, and 91.

This effect is thought to reflect category-specific

adapt

This effect is thought to reflect category-specific

adaptation processes. Similarly, presenting two faces concurrently also reduces the N170, suggesting that stimuli compete for neural representations in the occipito-temporal cortex as early as 170 ms. Here we compared the ERPs obtained for two faces or for a face and a phase-scrambled face in three different conditions: (1) a first stimulus (Si) followed by a second one (S2), similarly to previous adaptation paradigms; (2) S1 remaining on screen when S2 appeared, as previously used in studies of competition; (3) or S1 and S2 having simultaneous onset and offset as well. We found a significant and stimulus specific reduction of the N170 in both conditions where the onset of S1 preceded the onset Transmembrane Transporters inhibitor of S2. In contrast, simultaneous presentation of the two stimuli had no specific effect on the ERPs at least until 200 ms post-stimulus onset. This suggests either that competition does not lead to early repetition suppression or that the absence of a larger N170 response to two simultaneously presented face stimuli compared to a single stimulus reflects competition between overlapping representations. Overall, our results

show that the asynchronous presentation of S1 and S2 is critical to observe stimulus specific reduction of the N170, presumably reflecting adaptation-related processes. (C) 2013 Elsevier Ltd. All rights reserved.”
“Recent data have shown that TLR4 performs a key role in cerebral ischemia-reperfusion injury which serves as Ro-3306 mouse the origin of the immunological inflammatory reactions. However, the therapeutic effects of pharmacological inhibitions of TLR4 and its immediate down-stream pathway remain to be uncovered. In the present study, on mice, intracerebroventricular injection of resatorvid (TLR4 signal inhibitor; 0.01 mu g) significantly reduced VX-809 infarct volume and improved neurological score after middle cerebral artery occlusion and reperfusion. The levels of phospho-p38,

nuclear factor-kappa B, and matrix metalloproteinase 9 expressions were significantly suppressed in the resatorvid-treated group. In addition, NOX4 associates with TLR4 after cerebral ischemia-reperfusion seen in mice and human. Genetic and pharmacological inhibitions of TLR4 each reduced NOX4 expression, leading to suppression of oxidative/nitrative stress and of neuronal apoptosis. These data suggest that resatorvid has potential as a therapeutic agent for stroke since it inhibits TLR4-NOX4 signaling which may be the predominant causal pathway.”
“We report the oxidation of the InP(100) surface promoted by adsorbed Cs by synchrotron radiation photoemission. Oxygen exposure causes reduction in the charge transferred to the InP substrate from Cs and the growth of indium oxide and phosphorous oxide. The oxide growth displays a clear dependence on the Cs coverage.

It confirms the approach of mining large scale datasets as a robu

It confirms the approach of mining large scale datasets as a robust method to define reference genes, but cautions against using gene orthology or counterparts of reference genes in other plant species as a means of defining reference genes.”
“PTEN (phosphatase and tensin homolog deleted RG-7388 cost on chromosome 10) and MAST2 (microtubule-associated serine and threonine kinase 2) interact with each other through the PDZ domain of MAST2 (MAST2-PDZ) and the carboxyl-terminal (C-terminal) PDZ domain-binding site (PDZ-BS) of PTEN. These two proteins function as negative regulators of cell survival pathways, and silencing of either one promotes neuronal survival.

In human neuroblastoma cells infected with rabies virus (RABV), the C-terminal PDZ domain of the viral glycoprotein (G protein) can target MAST2-PDZ, and RABV infection triggers neuronal survival in a PDZ-BS-dependent fashion. These findings suggest that the PTEN-MAST2 complex inhibits neuronal survival and that viral G protein disrupts this complex through competition with PTEN for binding to MAST2-PDZ. We showed this website that the C-terminal sequences of PTEN and the viral G protein bound to MAST2-PDZ with similar affinities. Nuclear magnetic resonance structures of these complexes exhibited similar large interaction surfaces, providing

a structural basis for their binding specificities. Additionally, the viral G protein promoted the nuclear exclusion of PTEN in infected neuroblastoma

cells in a PDZ-BS-dependent manner without altering total PTEN abundance. These findings suggest that formation of the PTEN-MAST2 complex is specifically affected by the viral G protein and emphasize how disruption of a critical protein-protein interaction regulates intracellular PTEN trafficking. learn more In turn, the data show how the viral protein might be used to decipher the underlying molecular mechanisms and to clarify how the subcellular localization of PTEN regulates neuronal survival.”
“The aim of this study was to evaluate the clinical value of multislice 3-dimensional computed tomographic angiography (3D-CTA) in the preoperative assessment of meningiomas. A total of 331 cases with meningiomas confirmed by CT and MRI were examined using 3D-CTA. The locations of the tumors were observed to be as follows: parasagittal and falcine in 125 cases, sphenoidal in 39 cases, in the olfactory groove in 19 cases, tentorial in 21 cases, parasellar in 33 cases, petroclival in 29 cases, intraventricular in 7 cases and on the convexity of the brain in 58 cases. The reconstructed images were processed by shaded volume rendering, maximum intensity projection and color-shaded surface display. The 3D-CTA images were used to imitate the surgical approach. Surgery was performed according to the information provided in the 3D-CTA images.

In conclusion, the tumorigenic potential of implanted tungsten al

In conclusion, the tumorigenic potential of implanted tungsten alloys is related to mobilization of carcinogenic metals nickel and cobalt from corroding pellets, while gene expression changes in the consequent tumors are similar to radiation induced animal sarcomas as well as sporadic human sarcomas. Published by Elsevier Inc.”
“The biology of chronic myeloid leukemia (CML) has enabled pioneering studies Galardin with targeted therapies. BCR-ABL inhibition with imatinib results in high levels of efficacy in patients with newly diagnosed CML

in chronic phase (CP), but an estimated 35% of patients could benefit from more effective treatment. Several novel treatment strategies are being investigated in newly diagnosed CML-CP. These strategies include upfront treatment with next-generation tyrosine kinase inhibitors, such as dasatinib, nilotinib, or bosutinib, which also target BCR-ABL but with increased in vitro potency compared

with imatinib, and possibly a reduced potential for resistance. Recent in vitro studies have shown that short-term exposure to dasatinib or continuous exposure to imatinib result in equivalent levels of apoptosis, indicating that potent intermittent inhibition is a successful strategy for improving dasatinib tolerability. Modified imatinib regimens are also being investigated in newly diagnosed CML-CP, 3-MA order including higher doses and combination with alternative classes of agents, such as interferon. Existing data suggest that both newer agents and combination approaches can improve treatment responses compared with standard

imatinib treatment, although further data are needed, particularly from ongoing phase 3 trials, before the standard of care is revised. Clin Cancer Res; 16(6); 1771-80. (C) 2010 AACR.”
“Aim: The aim of the study was to evaluate the effect of isoflavones oil cardiovascular risk markers including plasma nitrite/nitrate, homocysteine, and lipid levels in Turkish women in the early postmenopausal period.\n\nMaterials and Methods: Ninety participants between 42 and 59 years of age were randomly assigned to receive twice a clay either selleck isoflavone tablet (n:45) or placebo tablets (n = 45). Plasma nitrite/nitrate, homocysteine, and lipid levels were Measured at baseline and after the 6 months of treatment.\n\nResults: After 6 months, isoflavone resulted in a statistically significant decrease in total cholesterol, low-density lipoproteins, triglyceride levels, serum homocysteine and an increase ill high-density lipoproteins and serum nitrites/nitrates. Lipoprotein-a level did not Change ill both groups.\n\nConclusions: Six months of treatment with isoflavones had a favorable effect oil serum nitrites/nitrates, homocysteine and lipid levels in Turkish women in the early postmenopausal period.

The average abundance and its range of the 5 phyla were as follow

The average abundance and its range of the 5 phyla were as follows: Firmicutes (63.7%, 29.1-84.1%), Proteobacteria (18.3%, 3.4-46.9%), Actinobacteria (6.8%, 0.4-39.9%), Bacteroidetes (7.6%, 2.2-17.7%) and Tenericutes (1.6%, 0.3-3%). Feeding the SAID resulted in significant shifts in the structure of the fecal microbial community when compared with the traditional COD. Among the 2116 OTUs detected in the present study, 88 OTUs were affected significantly by diet; and the proportion of these OTUs was 20.6% and 17.4% among the total number of sequences, respectively. Among the OTUs affected, the predominant species, including OTU2140

(G: Turicibacter), OTU1695 (G: Stenotrophomonas) and OTU8143 Fedratinib concentration (F: Lachnospiraceae), were increased, while the abundance of OTU1266 (S: Solibacillus silvestris) and OTU2022 (G: Lysinibacillus) was reduced in the SAID group compared with the COD. Further, our results indicated that the fecal volatile fatty acid (VFA) concentrations were significantly related to presence of some certain species of Bacteroidetes and Firmicutes in the feces.\n\nConclusions: this website This is, to our knowledge, the first study that has used barcoded DNA pyrosequencing to survey the fecal microbiome of

dairy cattle during SARA. Our results suggest that particular bacteria and their metabolites in the feces appear to contribute to differences in host health between those given SAID and traditional COD feeding. A better understanding of these microbial populations will allow for improved nutrient management and increased animal growth performance.”
“Many amphibians are explosive breeders, but the key factors that influence migrations to (and from) breeding sites are not well understood for all species. We used a comparative https://www.selleckchem.com/products/BafilomycinA1.html approach to compare and contrast the complex relationships among breeding chronology, environmental conditions, sexual dimorphism/body size, sex ratio, and genetic variation in Small-mouthed (Ambystoma texanum)

and Eastern Tiger Salamanders (Ambystoma tigrinum tigrinum). We intercepted 171 A. texanum and 330 adult A. t. tigrinum on their annual migration to breeding ponds over two consecutive breeding seasons (2003-04). Both species immigrated over a short period of time (4-17 days) and displayed no clear pattern regarding whether males or females typically arrived first at breeding ponds. Sex ratios were skewed toward males in both species but varied between years. Consistent with their expected sexual selection regimes, intraspecific sexual dimorphism was subtle in A. texanum but pronounced in A. t. tigrinum. There was no size-ordered immigration or emigration for either species examined; migration events were triggered by temperature and precipitation.