The difference of morphologies can be easily explained by the inf

The difference of morphologies can be easily explained by the influence of the molecular weight on the viscosity ratio and therefore, on the critical capillary number. The compatibilizing Selleckchem Proteasome inhibitor efficiency of copolymers containing glycidyl methacrylate groups was also addressed in

relation to their nature, the protocol for their drying and the molecular weight of the HDPE phase. The increase of adhesion between PET and HDPE was found to have a larger influence on tensile properties than the reduction of interfacial tension. The amount of compatibilizer needed for adhesion improvement depends on the interfacial area that is defined by both the interfacial tension and viscosity ratio of the components. A qualitative relation between the optimum amount of compatibilizer and the critical capillary number can be written. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 117: 1683-1694, 2010″
“The relation between germanium

monoxide (GeO) desorption and either improvement or deterioration in electrical characteristics of metal/GeO2/Ge capacitors fabricated by thermal oxidation has been investigated. In the metal/GeO2/Ge stack, two processes of GeO desorption at different sites and at different temperatures were observed by thermal desorption spectroscopy measurements. Go 6983 datasheet The electrical characteristics of as-oxidized metal/GeO2/Ge capacitors shows a large flat-band voltage shift and minority carrier generation due to the GeO desorption from the GeO2/Ge interface during oxidation

of Ge substrates. On the other hand, the electrical properties were drastically improved by a postmetallization annealing at low temperature resulting in a metal catalyzed GeO desorption from the top interface. (c) 2010 American Institute of Physics. [doi:10.1063/1.3452367]“
“Background and Objectives: The pathogenesis and the therapy of the yellow nail syndrome (YNS) are poorly defined. Our aim was to assess the clinical features, mTOR inhibitor associated diseases and response to treatment of patients with YNS, to help clinicians to better diagnose and treat YNS patients.

Patients and Methods: We studied the medical records of all patients with YNS diagnosed at the Outpatient Nail Clinic of the University of Bologna in the last 28 years. All patients were re-evaluated to assess the evolution of the disease.

Results: We diagnosed YNS in 21 patients; average age was 57 +/- 12.3 years at the time of diagnosis. In most patients YNS involved all 20 nails. Sixteen patients had chronic respiratory manifestations and 6 had lymphedema; 12 patients had other concomitant diseases. Ten of the 20 patients treated had a good nail response to systemic vitamin E 1 200 IU/day, while other symptoms were not modified.

Conclusions: YNS is a rare disorder in which the nail alterations are often the symptom that leads to medical consultation.

Therefore, this study compared 2 methods of bone augmentation, ho

Therefore, this study compared 2 methods of bone augmentation, horizontal DO and a bone-splitting (BS) method with bone graft, using an experimental dog model.

Study design. Five beagle dogs were studied. The experiments were designed in a spit-mouth manner. One side of the alveolar ridge of the mandible was 4 mm expanded using horizontal DO, followed by implant placement 2 months after augmentation. The other side of the ridge of the mandible was 4 mm augmented using a bone splitting (BS) method with a AZD0530 supplier bone graft combined with simultaneous implant placement.

Results. The average amount

of bone gain on the DO side (2.7 mm) was significantly greater than that on the BS side (1.7 mm) (P Stattic = .008) The keratinized soft tissue gain on the DO side (2.8 mm) was significantly greater than that on the BS side (0.6 mm) (P = .02). Resonance frequency analysis revealed that implants placed in the distracted area achieved good stability compared with those on the BS side. The implants were fully embedded in mature lamellar bone, and direct bone contact with the implant surface was seen 3 months after implant placement in the distracted area.

Conclusions.

Horizontal alveolar ridge distraction appears be an effective technique for the placement of implants in a narrow alveolar ridge. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009;107:350-358)”
“Background: An understanding of the factors that determine the risk of members of a susceptible population becoming infected is essential for estimating the potential for disease spread, as opposed to just focusing on transmission

from an infected population. Furthermore, analysis of the risk factors can reveal important characteristics of an epidemic and further develop understanding of the processes operating.

Methods: This paper describes the development of a mixed effects logistic regression model of susceptibility of holdings to foot and mouth disease (FMD) during the 2001 epidemic in Great Britain following the imposition of a national ban on the movements of susceptible animals (NMB).

Results: The principal risk factors identified in the model were shorter distances to the nearest infectious seed (a holding infected before the NMB) and the county of the holding Selleck Napabucasin (principally Cumbria). Additional risk factors included holdings that are mixed species rather than single species, the surface area of the holding, and the number of cattle within 10 km (all p < 0.001), but not surrounding sheep densities (p > 0.1). The fit of the model was evaluated using the area under the receiver operator characteristic curve (ROC) and the Hosmer and Lemeshow Chi-squared statistic; the fit was good with both tests (area under the ROC = 0.962 and Hosmer and Lemeshow Chi-squared statistic = 49.98 (p > 0.1)).

The details of the challenges encountered during diagnosis and tr

The details of the challenges encountered during diagnosis and treatment are further

discussed. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2009; 108:e20-e24)”
“Optical damage dynamics was investigated in as-grown, chemically reduced and oxidized nominally https://www.selleckchem.com/products/OSI-906.html pure LiNbO3, as well as in iron-doped LiNbO3 crystals. The self-arranged partial compensation of the optical damage for focused low-power 644-nm-laser beams was discovered in chemically reduced LiNbO3 crystals. During first stage of experiment, when the usual fast rise of the optical damage occurs, the transmitted power decreases from an initial to minimal value due to photorefractive defocusing, while the steady-state is achieved only after the long-term exposure, when a sequent slow increase in the transmitted power, indicating on self-compensation of the optical damage, is observed. It has been established, that this effect is caused by temperature gradient due to the inhomogeneous light-induced heating within small illuminated area of a bulk crystal. The electron hole competition in photoinduced charge carriers transport upon influence of inhomogeneous temperature field, the secondary and tertiary pyroelectric effects are shown to be responsible for most

important peculiarities of the self-compensation dynamics. (C) 2010 American Institute of Physics. [doi:10.1063/1.3452377]“
“Tungsten oxide and tungsten blues (WB) prepared by reducing the former with stannous chloride were capable of initiating the Dinaciclib bulk polymerization of N-vinylcarbazole (NVC) at the melting temperature of the latter (65 degrees C). The polymerizations were initiated by a eta(2)-type of complex formation involving pi-clouds of vinyl group and the available d-orbitals of W6+ ions. A composite of PNVC with WB was isolated

and characterized. Formation of PNVC and its incorporation in the composite was confirmed by FTIR, NMR, and UV absorption spectroscopic studies. Scanning electron micrographic analyses of PNVC-WB composite revealed Anlotinib solubility dmso the presence of close packed aggregates comprising particles of average sizes between 100-200nm range. TGA revealed the thermogravimmetric stability trend as WB > PNVC-WB > PNVC. Dc conductivities of PNVC-WB nanocomposite were found to depend on the WB : PNVC weight ratio in the composite and varied from 3.5 x 10(-4) (weight ratio 26) to 3 x 10(-2) S/cm (weight ratio 100) at room temperature. The threshold WB : PNVC weight ratio for the manifestation of conductivity in the composite was around 25 under the experimental condition of this study. (C) 2010 Wiley Periodicals, Inc. J Appl Polyrn Sci 117: 1371-1377,2010″
“Background: The tibial tubercle-trochlear groove (TT-TG) distance is a useful tool in guiding surgical management for patients with recurrent lateral patellar instability. Current recommendations for tibial tubercle transfer are based on TT-TG distance thresholds derived from adult populations.

The presence of the enhancers in the formulation produced well-fo

The presence of the enhancers in the formulation produced well-formed microparticles with different size and morphology, containing the drug well coated by the polymer. All the enhancers were able to increase the dissolution rate of Hd in the simulated intestinal environment without altering

CAP ability to protect Hd in the acidic fluid. The spray-drying technique and process Selleckchem MI-503 conditions selected were effective in microencapsulating and stabilizing the flavonoid giving satisfactory encapsulation efficiency, product yield, and microparticles morphology, and a complete drug release in the intestine.”
“Anti-insulin immunoglobulin G (IgG) has been found in the sera of healthy cats. To determine the concentrations

of these antibodies, an enzyme-linked immunosorbent assay (ELISA) for anti-insulin IgG was developed. ELISA maintained the linearity of a standard concentration line between 67.5 and 2160 ng/ml. The coefficients of variances (CVs) of intra-assays in two different plasma samples were 4.0% and 3.7%, respectively. The inter-assay CVs in two different plasma samples were 5.1% and 6.9%, VX-770 inhibitor respectively. The dilution curves of two samples were rectilinear. Anti-insulin IgG was detected in all 84 of the healthy cats that were tested. Plasma anti-insulin IgG concentrations ranged from 80 to 1578 mu g/ml, with a median concentration of 221 mu g/ml, and this value correlated positively with total plasma

IgG concentrations (r = 0.383, p < 0.01). In an intravenous glucose tolerance test, plasma anti-insulin IgG concentrations did not alter, even with changes in plasma glucose and insulin concentrations. The ELISA that was developed was able to determine plasma anti-insulin IgG in domestic cats, and confirmed that all healthy cats had plasma anti-insulin IgG. Determining the plasma concentrations of anti-insulin IgG in cats with various pathological conditions might clarify the role of anti-insulin IgG. (C) 2013 Selleckchem VX-661 Elsevier Ltd. All rights reserved.”
“Study Design. Computerized tomography of the subaxial cervical spine in 98 young, asymptomatic North American volunteers.

Objective. To provide normative data on subaxial transverse foramen dimensions and location in relation to surgical landmarks routinely used during operative intervention in the anterior cervical spine.

Summary of Background Data. Vertebral artery injury during anterior cervical spinal surgery is a rare but potentially catastrophic injury. There have been no prior studies in a large group of young, asymptomatic subjects without pathology and where the age, weight, and gender are known. There are no published computerized tomography data evaluating distances between the tip of the uncovertebral joint and the medial margin of the uncovertebral joint, 2 commonly used surgical landmarks.

Methods.

A 4-cell model involving

the interaction of CD4+ and CD8+

A 4-cell model involving

the interaction of CD4+ and CD8+ T cells recognizing major histocompatibility complex (MHC) class II on recipient antigen presenting cell (APC), and MHC class I on donor APC, has been proposed. However, this would require complex co-ordination between all the participating cell types. The semidirect pathway of alloantigen presentation suggests a simpler mechanism. Although exchange of MHC class II molecules between donor and recipient cells has been described, coexpression of recipient MHC molecules presenting donor derived allopeptides (indirect presentation) Selleck GDC-973 and donor MHC (direct presentation) on the same cell, a key requirement for the semidirect alloantigen presentation pathway, has not been demonstrated. We have used

a Milciclib mouse transplantation model to demonstrate the presence of cells expressing both donor MHC class I/II molecules, and a donor MHC class II peptide in the context of a recipient MHC class II molecule. This would allow indirectly activated CD4+ T cells to regulate directly activated CD4+ T cells, or to help directly activated CD8+ T cells, thus providing physical evidence for the semidirect pathway.”
“Angiogenesis is the growth of new blood vessels from existing vessels. Consequently, angiogenesis plays an essential role in tissue growth and repair, and in many diseases. In fact, any disturbances to angiogenic processes may lead to inappropriate growth and development, as well as several diseases. Apart from several angiogenic growth factors such as VEGF, PlGF, ANGPTL4 and PDGF, dietary fatty acids also modulate angiogenic processes directly or indirectly. Among these

fatty acids, n-3 fatty acids inhibit angiogenesis, whereas n-6 fatty acids stimulate angiogenesis. Although docosahexaenoic acid (22:6n-3) is widely known for its antiangiogenic activity, this fatty acid stimulates angiogenesis in first-trimester placental cells via increased synthesis of VEGF. This article explores these contrasting roles of docosahexaenoic acid in angiogenic processes and its possible effects on cell growth and disease processes.”
“The PD1:PDL1 pathway is an essential negative costimulatory pathway that plays a key role in regulating the alloimune response. PDL1 is expressed not only on antigen-presenting cells (APCs) but also cardiac endothelium. Ulixertinib in vivo In this study, we investigated the importance of PDL1 expression on donor cardiac allograft in acquired transplantation tolerance in a fully MHC-mismatched model. We generated PDL1 chimeric mice on B6 background that expressed PDL1 on either hematopoietic cells or nonhematopoietic cells of the heart. Sham animals were used as controls. These hearts were then transplanted into BALB/c recipients and treated with CTLA4-Ig to induce tolerance. Cardiac endothelium showed significant expression of PDL1, which was upregulated upon transplantation.

The gender distribution was 94 (58 08%) males and 68 (41 98%) fem

The gender distribution was 94 (58.08%) males and 68 (41.98%) females. The median

JQ-EZ-05 manufacturer age was 36.4 years. The main presenting symptom was neck swelling. All cases were evaluated with at least a computed tomography scan. The most common class of lesion was salivary-gland neoplasm, accounting for 74 cases (45.68%). The next most common group Of tumors was neurogenic, representing 68 cases (41.98%). Only 22 patients (13.58%) presented with malignant disease. Three surgical approaches were commonly used in the management of these lesions: transcervical-transparotid in 93 patients (57.41%), transcervical in 51 patients (31.48%), and transcervical-transmandibular in 18 patients (11.11%). Twenty patients with malignant disease underwent adjuvant chemotherapy and/or radiotherapy. All cases were followed for a mean of 36 months. There was no perioperative mortality. Two patients suffered local failure, and 4 patients developed distant metastasis during

the observation period.

Conclusions: Surgery is the mainstay treatment for PPS tumors. Surgical approaches were dictated by size of the tumor, its location, its relationship to the great vessels, and suspicion of malignancy. The most common approach was transcervical-transparotid for benign tumors. (C) 2009 American Association of Oral and Maxillofacial PF-00299804 price Surgeons J Oral Maxillofac Surg 67:1239-1244, 2009″
“Electric discharge excimer lasers are sustained in multi-atmosphere attaching gas mixtures that are typically preionized to enable a reproducible, uniform glow, which maximizes optical quality and gain. This preionization is often accomplished using UV light produced by a corona discharge within the plasma cavity. To quantify the relationship between corona discharge properties and those of the laser discharge, the triggering of electron avalanche by preionizing UV light in an electric discharge-pumped ArF* excimer laser was numerically investigated Bafilomycin A1 using a two-dimensional

model. The preionizing UV fluxes were generated by a corona-bar discharge driven by the same voltage pulse as the main discharge sustained in a multi-atmospheric Ne/Ar/Xe/F(2) gas mixture. The resulting peak photoelectron density in the inter-electrode spacing is around 10(8) cm(-3), and its distribution is biased toward the UV source. The preionization density increases with increasing dielectric constant and capacitance of the corona bar. The symmetry and uniformity of the discharge are, however, improved significantly once the main avalanche develops. In addition to bulk electron impact ionization, the ionization generated by sheath accelerated secondary electrons was found to be important in sustaining the discharge current at experimentally observed values. At peak current, the magnitude of the ionization by sheath accelerated electrons is comparable to that from bulk electron impact in the vicinity of the cathode. (C) 2011 American Institute of Physics. [doi: 10.1063/1.

In addition, there were 3 between-subject factors: budget (high c

In addition, there were 3 between-subject factors: budget (high compared with low), calorie-information (calorie information compared with no calorie information), and dietary restraint.

Results: Elasticity analyses show

a tax u calorie information interaction. A price increase https://www.selleckchem.com/products/GDC-0941.html for the high-calorie foods reduced the percentage of calories chosen for lunch but only in the absence of calorie information.

Conclusions: A tax of (3)25% on high-calorie foods may decrease the demand for calories and could be a good policy measure to decrease the prevalence of obesity. However, calorie information seems to interfere with the effect of a tax on high-calorie foods. Am J Clin Nutr 2011;93:689-94.”
“Cochlear implantation has altered the life-course of thousands of children who have significant hearing loss. Since the United States Food and Drug Administration approved multichannel cochlear implants for children in 1989, growing numbers of parents are choosing this option for their offspring

and seeking opportunities to integrate them into the hearing world of our society. When paired with appropriate habilitation, cochlear implantation removes barriers for children who are deaf. This technology affords them the ability to circumvent Acalabrutinib mw the effects of deafness and participate academically, socially, culturally, and vocationally with their hearing family and peers.”
“We study with finite temperature Monte Carlo simulation under periodic boundary conditions the demagnetization behavior of exchanged-coupled hard/soft magnets composed of hard cube inclusions (Nd2Fe14B, or SmCo5) in a soft (FeCo) matrix. The easy axis of the hard and soft phases are parallel

to the applied field. We study the effect of finite temperature and the soft phase content on the coercivity, the remanence, and the energy product of the composites. We find that because of the difference in magnetization between the two PXD101 molecular weight phases, to lower the dipolar energy the magnetization of the two phases is not completely parallel to each other. This results in a much smaller increase of the remnant magnetization with increasing the soft magnet content than anticipated, especially at higher temperatures. This, together with the lower coercivity of Nd2Fe14B, greatly affects the energy product in Nd2Fe14B/FeCo in comparison with SmCo5/FeCo. We underline the essential difference in the induction dependence on the applied field in these compounds. (C) 2011 American Institute of Physics. [doi:10.1063/1.3646474]“
“The introduction of new sensitive assays for the detection of HLA antibodies on basis of their binding to isolated HLA molecules has got an enormous impact on the decision-making process with respect to donor selection for sensitized patients.

In addition, the incidence of vascular penetration that is potent

In addition, the incidence of vascular penetration that is potentially hazardous

is included in the study.

Results. A total of 562 patients were performed 1305 times BIX 01294 inhibitor transforaminal lumbar epidural steroid. The overall incidence of vascular penetration encountered was 7.4%. Although major complications were not seen, the total rate of all minor complications was 11.5%. Whereas all of the minor complications were transient, the most frequent minor complication was vasovagal reaction (8.7%).

Conclusion. On the basis of the results of this study in which only minor complications were encountered, it can be said that the frequency of major complications is pretty rare in transforaminal lumbar epidural steroid injections in expert hands and in the conditions in which safety precautions are taken.”
“This 6-month CHIR99021 observational, prospective, multicenter study assessed the influence of changes in seizure severity on quality of life in patients with refractory partial epilepsy. Patients (N=262) diagnosed with partial epilepsy and receiving two antiepileptic drugs as determined by usual clinical practice were enrolled in this study. The primary endpoint was the mean seizure severity score obtained from

the Seizure Severity Questionnaire. Reductions in seizure severity were detected from baseline to months 3 and 6 (P<0.0001). Improvements compared with baseline were found for several secondary measures: Hamilton Anxiety and Depression scales (P<0.0001), most Medical Outcomes Study-Sleep subscales GW786034 supplier (P<0.05), and seven subscales of the Quality of Life in Epilepsy Inventory-31 (QOLIE-31; P<0.0005). Seizure severity correlated directly with anxiety (P<0.0001) and inversely with QOLIE-31 measures (P<0.0001). In conclusion, reducing seizure severity with appropriate medication may lead to improvement in the overall

quality of life of patients with refractory partial epilepsy. (C) 2010 Elsevier Inc. All rights reserved.”
“Research has shown that genetic polymorphisms in biotransformation enzymes, such as CYP1A1 and GSTM1, are related to a greater or lesser susceptibility to various cancers. We made an analysis of CYP1A1m1 SNP and GSTM1 null genotypes in a family group (71 members) related by consanguinity who had an unusually high incidence of cancer and a high frequency of smokers. There were no significant differences in genotype frequencies in this family when compared to data for Brazilian populations. Possibly, the high incidence of cancer in this sample is associated with smoking and/or other factors not detected in this survey.”
“Study Design. Case report.

Objective. To report bilateral pars fractures at L5 complicating a long fusion for adult idiopathic scoliosis in a patient with rheumatoid arthritis.

Summary of Background Data.

Blood pressure changes were not different between groups

Blood pressure changes were not different between groups.

Conclusions: The structured CLIP program was more effective than qualitative lifestyle advice in improving weight, waist circumference and LDL-cholesterol without

adverse effects on plasma carotenoids over a 6 week period. This program may therefore assist in comprehensive risk factor management, although the sustainability of these benefits needs confirmation. (C) 2009 Elsevier B.V. All rights reserved.”
“The Belnacasan in vivo presence of calcified lesions in the adrenal gland requires a careful endocrine, microbiological and radiological evaluation combined with detailed clinical history to confirm its non-evolving nature and avoid unnecessary surgery. We report an 18-month-old male child hospitalized with an incidentally discovered calcification in his right adrenal gland. All biochemical data as well as liver, renal and adrenal function tests were normal. Abdominal computed tomography scan showed that the right adrenal gland was completely occupied by a large calcification, which was put in relationship with an undetected adrenal distress during the neonatal period, as macrosomy and clavicle fracture of the newborn could let us suggest. Our report describes the diagnostic approach to disclose

the nature of a suprarenal mass, which is particularly problematic when this is found incidentally. In addition, an extensive review of the medical literature dealing with non-traumatic adrenal www.selleckchem.com/products/GSK690693.html calcifications and haemorrhages in children has been carried out.”
“Background: Experimental animal studies have shown adverse effects of high-dose vitamin C supplements on age-related cataract.

Objective: We examined whether vitamin C supplements (approximate to 1000 mg) and multivitamins containing vitamin C (approximate to 60 mg) are associated with the incidence of age-related cataract extraction in a population-based, prospective cohort of women.

Design: Our study included 24,593 women aged 49-83 y from the Swedish Mammography Cohort (follow-up from September 1997 to October 2005). We collected information

on dietary supplement use Selleckchem Etomoxir and lifestyle factors with the use of a self-administrated questionnaire. Cataract extraction cases were identified by linkage to the cataract extraction registers in the geographical study area.

Results: During the 8.2 y of follow-up (184,698 person-years), we identified 2497 cataract extraction cases. The multivariable hazard ratio (HR) for vitamin C supplement users compared with that for nonusers was 1.25 (95% CI: 1.05, 1.50). The HR for the duration of >10 y of use before baseline was 1.46 (95% CI: 0.93, 2.31). The HR for the use of multivitamins containing vitamin C was 1.09 (95% CI: 0.94, 1.25). Among women aged >= 65 y, vitamin C supplement use increased the risk of cataract by 38% (95% CI: 12%, 69%).

CONCLUSIONS: Our findings indicate that a novel synonymous SNP in

CONCLUSIONS: Our findings indicate that a novel synonymous SNP in PITX3 gene may contribute to PD risk in the Chinese population.”
“Background: Patients with type IIb, or mixed, dyslipidemia have high levels of low-density lipoprotein cholesterol (LDL-C) with predominance of small dense

LDL particles, high levels of triglycerides (TG), and low levels of high-density lipoprotein cholesterol (HDL-C). Fenofibrate significantly reduces TG and, more moderately, AZD1480 nmr LDL-C, increases HDL-C and produces a shift from small to large LDL particle size; the main effect of ezetimibe is a reduction in LDL-C levels. Combined treatment with fenofibrate and ezetimibe may correct all the abnormalities of type IIb dyslipidemia.

Objective: To assess the efficacy and safety of coadministration of fenofibrate (NanoCrystal (R)) and ezetimibe in patients with type IIb dyslipidemia and the metabolic syndrome compared with administration of fenofibrate and ezetimibe alone (ClinicalTrials.gov Identifier: NCT00349284; Study ID: CLF178P0401).

Methods: This was a prospective, randomized, double-blind, three-parallel arm, multicenter, comparative study. Sixty ambulatory patients (mean age 56 years; 50% women, 50% men) were treated in each group. For inclusion in the study, patients were required to have LDL-C >= 4.13mmol/L (>= 160mg/dL), TG >= 1.71 mmol/L https://www.selleckchem.com/products/SB-202190.html and <= 4.57 mmol/L (>= 150 mg/dL and <= 405 mg/dL), and at least

BAY 63-2521 mw two of the following National Cholesterol Education

Program Adult Treatment Panel III criteria for the metabolic syndrome: low HDL-C or increased fasting plasma glucose, blood pressure, or waist circumference. Patients received fenofibrate 145 mg, ezetimibe 10 mg, or coadministration of both (fenofibrate/ezetimibe) daily for 12 weeks. The outcome measures were changes in lipids and related parameters, apolipoproteins, glucose metabolism parameters, and high-sensitivity C-reactive protein (hsCRP).

Results: Fenofibrate/ezetimibe was more effective than either fenofibrate or ezetimibe in reducing LDL-C. (-36.2% vs -22.4% and -22.8%, respectively), non-HDL-C (-36.2% vs -24.8% and -20.9%, respectively), total cholesterol (TC) [-27.9% vs -18.9% and -17.1%, respectively], apolipoprotein B (-33.3% vs -24.5% and -18.7%, respectively), TC/HDL-C ratio (-34.2% vs -23.0% and -17.0%, respectively), and apolipoprotein B/apolipoprotein AI ratio (-37.5% vs -27.0% and -17.7%, respectively) [p < 0.001 for all comparisons between fenofibrate/ezetimibe and monotherapies]. Fenofibrate/ezetimibe was as effective as fenofibrate and more effective than ezetimibe in reducing remnant-like particle cholesterol (-36.2% and -30.7% vs -17.3%, respectively), and in increasing LDL size (+ 2.1 % and + 1.9% vs + 0.7%. respectively), apolipoprotein AI (+ 7.9% and + 5.1 % vs + 0.2%, respectively) and apolipoprotein All (+ 24.2% and + 21.2% vs + 2.7%, respectively).