“
“Palliative sedation (sedation to unconsciousness) as an option of last resort for intractable end-of-life distress has been the subject of ongoing discussion and debate as well as policy formulation. A particularly contentious issue has been whether some dying patients experience a form of intractable suffering not marked by physical symptoms that can reasonably be characterized as “”existential”" in nature and therefore not an acceptable indication for palliative sedation. Such is the position recently

taken by the American Medical Association. In this essay we argue that such a stance reflects a fundamental misunderstanding of the nature of human suffering, particularly at the end of life, and may deprive some dying patients of an effective means of relieving their intractable terminal distress.”
“The prevalence of unruptured intracranial aneurysms (UIAs) in the general population is up to 3 %. Existing epidemiological data suggests that only Z-IETD-FMK solubility dmso a small fraction of UIAs progress towards rupture over the lifetime of an individual, but the surrogates for subsequent rupture and the natural history of UIAs are discussed very controversially at present. In case of rupture of an UIA, the case fatality

is up to 50 %, which therefore continues to stimulate interest in the pathogenesis of cerebral aneurysm formation and progression. CA3 Actual data on the chronological development of cerebral aneurysm has been especially difficult to obtain and, until recently, the existing knowledge in this respect is mainly derived from animal or mathematical models or short-term observational studies. Here, we review the current data on cerebral aneurysm formation and progression as well as a novel approach to investigate the developmental chronology of cerebral aneurysms.”
“To examine if pre-injury health-related factors are associated with the subsequent report of whiplash, and more specifically, both whiplash and neck pain.

Longitudinal population study of 40,751 persons participating in two consecutive health surveys with 11 years interval. We used logistic regression to estimate odds ratio (OR) for reporting whiplash

or whiplash with neck pain lasting at least 3 months last year, related to pre-injury health as indicated by subjective SRT1720 in vitro health, mental and physical impairment, use of health services, and use of medication. All associations were adjusted for socio-demographic factors.

The OR for reporting whiplash was increased in people reporting poor health at baseline. The ORs varied from 1.47 (95% CI 1.13-1.91) in people visiting a general practitioner (GP) last year to 3.07 (95% CI 2.00-4.73) in people who reported poor subjective health. The OR associated with physical impairment and mental impairment was 2.69 (95% CI 1.75-4.14) and 2.49 (95% CI 1.31-4.74), respectively. Analysis of reporting both whiplash and neck pain gave somewhat stronger association, with ORs varying from 1.50 (95% CI 1.07-2.