These Fe-Co-Hf films deposited by the composition gradient sputtering method exhibited a high saturation magnetization of 1.8-2.2 T, a large uniaxial anisotropy field of 200-500 Oe, and a high ferromagnetic resonance frequency over 7 GHz, which provides great opportunities for integrated magnetic devices. (C) 2011 American Institute of Physics. [doi: 10.1063/1.3549584]“
“Src kinase mutations and/or overexpression have been implicated in the development of a number of human cancers including colon, breast, and lung cancers. Thus, designing potent and selective Src

kinase inhibitors as anticancer agents is a subject of major interest. A series of 4-aryl substituted derivatives of 2-amino-7-dimethylamino-4H-chromene-3-carbonitrile were synthesized using one-pot reaction of appropriate substituted aromatic aldehydes, malononitrile, and 3-(dimethylamino)phenol in the presence of piperidine. All 23 compounds were evaluated for inhibition 4-Hydroxytamoxifen datasheet of Src kinase and cell proliferation in human colon adenocarcinoma (HT-29) and leukemia (CCRF-CEM) cell lines. Among the tested compounds, 2-chlorophenyl- (4c), 3-nitrophenyl- (4h), 4-trifluoromethyphenyl- (4i), and 2,3-dichlorophenyl-

(4k) substituted chromenes showed Src kinase inhibitory effect with IC50 values of 11.1-18.3 mu M. Compound 4c was relatively selective against Src (IC50 = 11.1 mu M), when compared with selected kinases, epidermal growth factor receptor (EGFR, IC50 > 300 mu M), C-terminal Src kinase (Csk, IC50 = 101.7 mu M), and lymphocyte-specific protein tyrosine kinase (Lck, IC50 = 46.8 mu M). 3-Chlorophenyl substituted thiazole (4v) and 2-chlorophenylsubstituted selleck inhibitor VX 770 thiazole (4u) chromene derivatives inhibited the cell proliferation of HT-29 and CCRF-CEM by 80% and 50%, respectively, at a concentration of 50 mu M. The data indicate that 4H-chromene-3-carbonitrile scaffold has the potential to be optimized further for designing more potent Src kinase inhibitors and/or anticancer

lead compounds.”
“We present a theoretical study of electron mobility in modulation-doped AlSb/InAs quantum wells. The theory also accounts for the nonparabolicity effect. All major scattering mechanisms, including scattering by deformation potential and piezoelectric acoustic phonons, polar optical phonons, ionized impurities, and interface roughness, have been included in our calculations. The low field transport properties of the two dimensional electron gas (2DEG) in the AlSb/InAs quantum wells are studied as a function of temperature, quantum well width, and spacer width and strategies for optimizing the 2DEG mobility are discussed. Depending on the quantum well parameters, the high-mobility limit in this quantum well structure may be determined by either ionized impurity scattering or interface-roughness scattering. The calculated 2DEG mobilities are in very good agreement with the reported experimental data for modulation-doped AlSb/InAs quantum wells. (C) 2011 American Institute of Physics. [doi:10.1063/1.