The aim of this research was to conduct a systematic review on the association between dental erosion (DE) and gastroesophageal reflux disease (GERD) and the effect of saliva’s flow rate, buffering capacity and oral microbial changes caused by GERD. Methods: All descriptive, analytical studies up to December 2011 that have relevant objectives,

proper sampling method and sufficient results were included by searching PubMed and Scopus electronic data bases. Results: Fifteen studies were selected according to our inclusion criteria (10 in adult and 5 in children population). There was a strong association between DE and GERD in the adult population, and the relationship in the children population GSK-3 inhibition was found to be of less importance. Conclusion: Early diagnosis and treatment of refluxed acid in both age groups through lifestyle changes and medications an prevent further damage and tooth loss Key Word(s): 1. Dental Erosion; 2. GERD; 3. saliva; 4. systemic review; Presenting

Author: PEIQIN WANG Additional Authors: CHENGDANG WANG Corresponding Metformin chemical structure Author: PEIQIN WANG, CHENGDANG WANG Affiliations: Department of Gastroenterology, The First Affiliated Hospital of Fujian Medical University Objective: Diarrhea-predominant irritable bowel syndrome (IBS-D) is characterized by elevated colonic luminal serine proteases activity, which may be come from gut bacteria. The aims of this study were (1) to analysis the relationship of fecal serine proteases activity with IBS symptoms, small intestinal bacterial overgrowth (SIBO), serum interleukin-6 (IL-6) and erythrocyte sedimentation rate (ESR), (2) to study the effects of antibiotics

and probiotics on fecal serine proteases activity and IBS symptoms improvement. Methods: Fecal serine proteases activity, lactulose hydrogen breath test (LHBTs), IL-6, and ESR were detected in 65 cases of patients with IBS-D. Antibiotics learn more and probiotics (metronidazole 0.4 tid+ levofloxacin 0.2 bid+ Bifico 0.42 bid) were administrated to 14 patients with LHBT-positive IBS-D for one week, and the alteration of fecal serine proteases activity and symptoms improvement were investigated. Results: (1) A positive correlation was detected between fecal serine proteases activity and the degree of abdominal pain discomfort (r = 0.37, P = 0.007). (2) The activity of fecal serine proteases was no significant difference between LHBT-positive (5.23∼130.62 (median 24.81) U/mg protein) and negative (26.06∼177.77 (median 52.80) U/mg protein) IBS-D patients (P = 0.18).