SRT1720 molecular weight RMN13C (δppm, DMSO) 11.26 (CH3); 14.03 (CH3); 14.07 (CH3); 30.19 (CH2); 67.92 (CH2); 105.58 (C-6); 114.96 (C-3a); 120.64 (C-2′ and C-6′), 125.99 (C-4′), 129.69 (C-3′ and C-5′), 139.45 (C-1′),143.25 (C-10a),154.76 (C-3), 156.97 (C-5), 159.15 (C-9), 162.04 (C-4a), 162.50 (C-7), 164.09 (CO); HRMS Calcd.   h) Ethyl-7-imino-N 1 -phenyl-1,7-dihydropyrazolo[3′,4′:4,5]pyrimido[1,6-a]pyrimidine carboxylate 5h Yield 89 %; mp 184 °C; IR (cm−1); ν NH 3227; ν CO 1710; ν C=N 1539, 1552, 1574.17; RMN 1H (δ ppm, DMSO) 1.29 (3H, t, J = 7.0 Hz, CH3); 4.24 (2H, q, J = 7.0 Hz, CH2); 7.37 (1H, t, J = 7.3 Hz, ArH4); 7.55 (2H, t, J = 7.3 Hz, ArH3 and ArH5); 8.14 (2H, d, J = 7.3 Hz, ArH2 and ArH6); 8.75 (1H, s, Ion Channel Ligand Library price H5); 8.83 (1H, s, H9); 9.18 (1H, s, H3); 12.11 (1H, s, NH). RMN13C (δ ppm, DMSO) 14.11 (CH3); 61.36 (CH2); 103.83 (C-6); 114.46 (C-3a); 120.62 (C-2′ and C-6′), 126.73 (C-4′), 129.20 (C-3′ and C-5′), 134.35 (C-1′),138.10 (C-10a),148.14 (C-3), 151.37 (C-5), 153.53 (C-9), 154.00 (C-4a), 155.18 (C-7), 163.36 https://www.selleckchem.com/products/Tipifarnib(R115777).html (CO). 120.62-126.73-129.20-134.35, C17H14N6O2, 334.1171; HRMS Calcd. for: C17H14N6O2: 334.1178, found: 334.1171.   i) Ethyl-5-methyl-7-imino-N 1 -phenyl-1,7-dihydropyrazolo[3′,4′:4,5]pyrimido[1,6-a] pyrimidine-6-carboxylate

5i Yield 78 %; mp 166 °C; IR (cm−1); ν NH 3059; ν CO 1718; ν C=N 1579, 1591, 1612; RMN 1H (δ ppm, DMSO) 1.34 (3H, t, J = 7.0 Hz, CH3); 1.92 C-X-C chemokine receptor type 7 (CXCR-7) (3H, s, J = 7.1 Hz, CH3); 4.02 (2H, q, J = 7.0 Hz, CH2); 7.30 (1H, t, J = 7.3 Hz, ArH4);

7.61 (2H, t, J = 7.3 Hz, ArH3 and ArH5); 8.10 (2H, d, J = 7.3 Hz, ArH2 and ArH6); 9.29 (1H, s, H3); 9.49 (1H, s, H9); 11.95 (1H, s, NH). RMN13C (δ ppm, DMSO); 15.06 (CH3); 23.14 (CH3); 69.54 (CH2); 102.85 (C-3a); 117.05 (C-6); 121.637 (C-2′ and C-6′), 126.41 (C-4′), 128.65 (C-3′ and C-5′), 139.24 (C-1′),143.92 (C-10a),144.17 (C-3), 159.62 (C-5), 161.45 (C-9), 167.12 (C-4a), 167.83 (C-7), 168.28 (CO); HRMS Calcd. for C18H16N6O2: 348,1335, found 348,1274.   Pharmacology Carrageenan (BDH Chemicals Ltd., Poole, England), cimetidine and acetylsalicylic–lysine were purchased from pharmacie Centrale of Tunisia. Animals Adult Male Wistar rats weighing 150–170 g were obtained from Pasteur Institute (Tunis, Tunisia). They were housed in polypropylene cages and left for 2 days for acclimatization to animal room maintained under controlled conditions: a 12 h light–dark cycle (at 22 ± 2 °C) on standard pellet diet and water ad libitum.