In this retrospective study, 456 customers with CRC which obtained surgical procedure in the division of General operation, Affiliated Hospital of Nantong University from January 2016 to February 2018 had been examined. Preoperative CYFRA 21-1, CEA, CA19-9 and pathological data regarding the research topics were gathered. Establish the cut-off value of CYFRA 21-1 on the basis of the classification of genetic variants X-tile. Chi-square test or Fisher exact probability test were utilized to compare clinicopathological functions in various CYFRA 21-1 level groups. Univariate and multivariate regression analysis of factors affecting 5-year overall survival (OS) and disease-free survival (DFS). Kaplan-Meier success curves were used to evaluate 5-year differences in androgen biosynthesis OS and DFS in CRC customers with different amounts of CYFRA 21-1, CEA and CA19-9. Receiver operating characteristic(ROC) ended up being followed. ROC curves were utilized to evaluate the prognostic efficacy of CYFRA21-e C-indexes had been 0.799 and 0.803, respectively. In summary, preoperative serum CYFRA 21-1 level are an independent threat factor impacting the prognosis of patients with colorectal disease. The prognostic design established by CYFRA 21-1 coupled with CEA, CA19-9 and TNM phases may provide references when it comes to avoidance of CRC recurrence and clinical decision-making.This study aims to produce an immediate and convenient test card for simultaneous recognition of influenza A and influenza B viruses making use of quantum dot-based immunochromatographic assay. The test card contains a test strip and a plastic casing. The test strip comprises absorbent report, a buffer pad, nitrocellulose membrane layer (NC membrane), test pad, quantum dot-labeled antibody pad, and polyvinyl chloride (PVC) board. The NC membrane is covered with mouse monoclonal antibodies against influenza A and influenza B viruses for the T lines (test outlines), and research proteins A and B when it comes to C range (control line). The quantum dot-labeled antibody pad includes mouse monoclonal antibody-quantum dot conjugates against influenza A and influenza B viruses. The outcome showed that the detection limitation for the test card both for viruses ranged from 1.51 ×102 to 2.71×103 TCID50/ml, indicating its susceptibility for precise detection of influenza A and influenza B viruses without having to be afflicted with different variants. The test card displayed specific responses with different subtypes of influenza A and influenza B virus culture fluids and showed no cross-reactivity with adenovirus, unique coronavirus, Mycoplasma pneumoniae, respiratory syncytial virus, Staphylococcus aureus, as well as other pathogens. Overall, the sensitiveness and specificity associated with the test card for multiple detection of influenza A and influenza B viruses meet with the needs for medical usage. It provides the benefits of ease, rapidity, and no requirement for unique equipment, allowing quick auxiliary analysis to avoid condition transmission.Using device learning algorithms to make an earlier prediction model of brucellosis to improve the analysis performance of Brucellosis. This study ended up being a case-control research. 2 381 brucellosis customers from Beijing Ditan Hospital affiliated to Capital health University had been retrospectively collected as instance team, and healthy people from Beijing Chaoyang Hospital affiliated to Capital health University were gathered as control group from might 9, 2011 to November 29, 2021. The relevant clinical information and full-blood matter outcomes of 13 257 information had been gathered and five formulas of device discovering were used to construct an early predication type of brucellosis simply by using machine learning random forest, Naive Bayes, decision tree, logistic regression and support vector machine;14 074 data (2 143 cases incase group and 11 931 cases in charge team) were utilized to ascertain early predication type of brucellosis, and 1 564 (238 instances just in case group and 1 326 cases in control team) information were utilized to te brucellosis patients.To investigate the relationship between male semen parameters and sperm DNA fragment list with age. Adopt cross-sectional sampling survey design, 3 203 male patients which went to the division of Reproductive Andrology into the Third Affiliated Hospital of Zhengzhou University from January 2019 to June 2021 were selected as topics. A long time is 18-57 years, with all the median age of three decades Nutlin-3a . Through quartile regression evaluation, the correlation between age and different male semen variables and DNA fragment index (DFI) ended up being presented. The study populace ended up being split into ≤30 yrs . old team and >30 yrs . old group, and the correlation between age and semen volume, sperm focus, complete sperm fertility, modern motility, complete motility, percentage of normal semen and DFI amount were contrasted and reviewed. The outcome indicated that there have been considerable differences in modern motility, total motility and DFI amount among different age ranges (χ2=-4.608, -4.604, -7.719,P all 0.05). In conclusion, using the enhance of age, particularly following the chronilogical age of 30, semen volume, modern motility and complete motility reduced, while sperm concentration and DFI level enhanced, and semen quality decreased.To investigate the medical efficacy and security of dupilumab within the treatment of reasonable to severe atopic dermatitis (AD) in China. A small sample self-controlled study before and after therapy had been performed to retrospective evaluation patients with moderate to severe advertising addressed with dupilumab when you look at the division of dermatology of this First Affiliated Hospital of Chongqing Medical University from July 2020 to March 2022. Dupilumab 600 mg ended up being injected subcutaneously at week 0, after which 300 mg ended up being injected subcutaneously every 2 weeks. The condition was assessed by SCORAD(severity scoring of atopic dermatitis), NRS(numerical rating scale), DLQI(dermatology life high quality index) and POEM(patient-oriented eczema measure). The improvement of SCORAD, NRS, DLQI and POEM ended up being analyzed by paired t ensure that you non-parametric paired Wilcoxon. The outcome showed that an overall total of 67 customers with modest to serious AD received dupilumab treatment, of which 41 clients (this course of treatment was significantly more than 6 days) had paid down t6, POEM (18.04±6.41) at standard, POEM (9.70±4.70)(t=7.031,P less then 0.001) at week 4, POEM (7.74±3.48)(t=8.806,P less then 0.001) at week 8, POEM (6.35±3.33)(t=10.474,P less then 0.001) at week 12, POEM (4.26±2.51)(t=11.996,P less then 0.001) at few days 16. When you look at the sixteenth week, 100%(23 customers), 91.3%(21 customers), 34.8%(8 patients) and 8.7%(2 clients) of 23 customers reached SCORAD30, SCORAD50, SCORAD70, and SCORAD90 statuses, respectively.