Over half are cirrhotic (63%), genotype 1a (56%) and prior non-re-sponders to treatment (52%). We found significant worsening in both IFN-based and IFN-free treated patients from baseline to week-4 in terms physical functioning (-5.9%, p=0.008 and -6.3%, p<0.001 respectively) Selleck Ivacaftor with no significant difference between the groups. The IFN-free group also experienced significant worsening in energy (-8.3%, p=0.009) and pain (-11.7%, p=0.009) from baseline to week-4. The IFN-based group had significant worsening in FSS (mean change:

+1.6, p=0.006) whereas the IFN-free group reported a smaller and non-significant change from baseline (+0.6, p=0.06). In terms of side effects, the IFN-based group experienced increased irritability (+2.0, p=0.009) and itching (+1.0, p=0.009), whereas the IFN-free group reported increased physical tiredness (+1.5, p=0.02). Conclusions: Real world patients treated with IFN-free regimens experience worsened physical symptoms at week-4 of treatment Alectinib solubility dmso similar to the worsening reported by patients treated with IFN-based regimens. Continued enrollment and follow-up may reveal further differences between IFN-based and IFN-free regimens as well as elucidate the role of ribavirin in these reported symptoms. NIH funded (DA031095, DK090317). Disclosures: Kian Bichoupan – Consulting: Janssen Pharmaceuticals, Gilead Sciences

Alyson Harty – Advisory Committees or Review Panels: Gilead; Consulting: Gil-ead, Jannsen, Acaria Pharmacy Jeffrey J. Weiss – Consulting: Vertex; Grant/Research Support: Cephalon Thomas D. Schiano – Advisory Committees or Review Panels: vertex, salix, merck, gilead, pfizer; Grant/Research Support: massbiologics, itherx Douglas Dieterich – Advisory Committees or Review Panels: merck, Idenix, Jans-sen ; Consulting: Gilead, BMS Andrea D. Branch – Grant/Research Support: Kadmon, Gilead, Janssen The following people have nothing to disclose: Jillian Nickerson, Ponni Perum-alswami Background/Aim Hepatitis

C virus (HCV) is a leading cause of hepatocellular carcinoma (HCC) in Japan. We aimed to elucidate the clinical features of chronic hepatitis C patients who develop HCC after achieving a sustained viral response (SVR) to interferon (IFN) therapy. Methods Clinical RVX-208 parameters of 146 patients (mean age: 59 years old, male: 88, female: 58) were evaluated who achieved a SVR from 1991 to 2013 in our hospital. Results Eleven patients (7.5 %) developed HCC within a median follow-up period of 62 months (range12–271 months). Cox regression analysis revealed that the strongest factor predictive of HCC occurrence was higher AST (>50IU/L) level (hazard ratio [HR] 6.51, P=0.024), followed by lower platelet (<17x104 cells/microL) count (HR 4.39, P=0.318), prolonged (<80%) prothrombin time (HR 3.69, P=0.047), higher gamma-GTP(>70IU/L) level HR 3.66, P=0.045) before IFN therapy.