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do not have any potential competing interests. Authors’ contributions PQL, QAP, LXJ and MCJ conceived and designed the study, CZP, SJZ, WJR, ZLM, YS, QX, and LS participated in selecting study, extracting data, performing the statistical analysis and drafting IKBKE the manuscript. PQL has been involved in revising the manuscript critically for important intellectual content. All authors read and approved the final manuscript.”
“Background Lung cancer is the most common cancer and the leading cause of cancer deaths around the world [1]. Although prognosis of patients can be improved through effective treatment, the 5-year survival rate of patients with advanced lung cancer is only 10%-15% [2]. Non-small cell lung cancer (NSCLC) accounts for 70%-80% in lung cancer, and among them, lung adenocarcinoma (LAD) accounting for almost half of lung cancers, was one of the most common histologic subtype. Patients with LAD had rapid disease progression, and recurrence ratio was high even after surgery.