Conclusion: It is critical for the rehabilitation of patients with mild acute pancreatitis to observe and analyze

the causes of serum amylase unfalling and Epigenetics inhibitor take effective measures to deal with. Key Word(s): 1. acute pancreatitis; 2. serum amylase; 3. analysis; 4. treatment; Presenting Author: CHENWEN JING Additional Authors: TANGGUO DU Corresponding Author: TANGGUO DU Affiliations: guangxi medical university Objective: To investigate the relationship between AOPP and severity of AP by detecting serum levels of AOPP in patients with AP, combination the results of serum interleukin -6(IL-6), indicators which associated with disease severity and clinical datas. Methods: Fifty-eight patients who were diagnosed acute pancreatitis in our hospital from November 2010 to September 2012 were collected[18 cases with severe acute pancreatitis (SAP) and

40 cases with mild acute pancreatitis (MAP)]. Serum levels of AOPP and IL-6 were dectected by enzymelinked immunosorbent assay (ELISA) within 24 hours. Blood samples were sent to the laboratory to dectect blood routine, liver function, renal function, blood calcium, blood glucose and actate dehydrogenase. APACHE II scores, Ranson scores, CTSI scores, BISAP scores and Glasgow scores were also determined. Results: ① Serum levels of WBC, GLU, LDH in SAP group were higher than MAP group (P < 0.05). ALB and check details blood calcium in SAP group was lower than MAP group (P < 0.05). ② Serum levels of BUN, Cr, blood amylase were no significant difference between SAP FDA approved Drug Library clinical trial group and MAP group (P > 0.05). ③ In SAP group and MAP group, APACHE II scores were (5.00 ± 3.67) and (3.39 ± 2.91), Ranson scores were (2.04 ± 1.46) and (1.33 ± 1.21), CTSI scores were (5.87 ± 1.46) and (1.20 ± 1.26), BISAP scores were (1.52 ± 0.80) and (0.86 ± 0.76), Glasgow scores were (2.61 ± 1.20) and (1.24 ± 1.12), respectively, and SAP group was higher than MAP group (P < 0.05). ④ Serum levels of AOPP in

SAP group and MAP group were (38.1156 ± 11.67)ng/ml and (29.40 ± 14.19)ng/ml, respectively, and SAP group was higher than MAP group (P < 0.05). Serum levels of IL-6 in SAP group and MAP group were (211.01 ± 107.98)pg/ml and (129.72 ± 56.53)pg/ml, respectively, and SAP group was higher than MAP group (P < 0.05). ⑤ There are relations between AOPP and WBC, GLU (P < 0.05), but no relations with LDH, blood calcium, ALB, BUN, Cr and blood amylase (P > 0.05). Conclusion: Serum levels of AOPP may be associated with the severity of AP; AOPP may be associated with the process of inflammatory response in the occurrence and development of AP; AOPP and indicators which associated with disease severity may be used as markers to estimate the severity in AP. Key Word(s): 1. acute pancreatitis; 2. AOPP; 3.