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“Chapter 1: Diagnosis and significance of CKD Is CKD a risk factor for ESKD? Seliciclib chemical structure CKD was defined for the first time in one of the clinical guidelines of the K/DOQI published in 2002 by NKF. CKD stages 3–5 have been known as risk factors for ESKD. In the Japanese population, eGFR ≤50 ml/min/m2
in patients aged 40–69 years and 40 ml/min/1.73 m2 in patients aged 70 years and over are risk factors for ESKD. Proteinuria and albuminuria are also proportionally related to the risk for ESKD. A meta-analysis of 11 observational studies of non-diabetic nephropathy indicated that proteinuria before treatment was a strong prognostic factor for the doubling of serum creatinine and ESKD. This finding could be extrapolated to a normal population and pretreated CKD patients and those on current treatment. Decreased proteinuria and albuminuria by RAS inhibitors are implicated in the suppression of progression of CKD. Bibliography 1. Fluorometholone Acetate Drey N, et al. Am J Kidney Dis. 2003;42:677–84. (Level 4) 2. Keith DS, et al. Arch Intern Med. 2004; 164:659–63. (Level 4) 3. Patel UD, et al. Am J Kidney Dis. 2005;46:406–14. (Level 4) 4. Evans M, et al. Am J Kidney Dis. 2005;46:863–70. (Level 4) 5. Eriksen BO, et al. Kidney Int. 2006;69:375–82. (Level 4) 6. Kovesdy CP, et al. Adv Chronic Kidney Dis. 2006;13:183–8. (Level 4) 7. Norris KC, et al. J Am Soc Nephrol. 2006;17:2928–36. (Level 4) 8. buy AZD5582 Serrano A, et al. Adv Chronic Kidney Dis. 2007;14:105–12. (Level 4) 9. Imai E, et al. Hypertens Res. 2008;31:433–41. (Level 4) 10. Wu MJ, et al. J Chin Med Assoc. 2010;73:515–22. (Level 4) 11. Levey AS, et al. Kidney Int. 2011;80:17–28. (Level 4) 12. Iseki K, et al. Kidney Int. 2003;63:1468–74. (Level 4) 13. Zhang Z, et al. J Am Soc Nephrol. 2005;16:1775–80. (Level 4) 14.