268, 95% confidence interval [CI] 1.253-84-129, P=0.046) and 8.1-13 kPa (HR=7.877, 95% CI, 1.150-65.312, P=0.046) were

at significantly greater risk of developing LREs than those with a LS value ≤8 kPa, as a reference. On multivariate analysis using the Cox regression method, age and LS values were identified as independent predictors of LRE development (both P<0.05). Conclusion: The LS value at the time of CVR is a useful predictor of future LREs. Despite complete viral suppression through antiviral therapy, more careful surveillance is necessary, particularly in patients with a LS >8 kPa. Disclosures: The following people have nothing to disclose: Hye Won Lee, Seung Up Kim, Beom Kyung Kim, Tamoxifen purchase Jun Yong Park, Do Young Kim, Sang Hoon Ahn, Kwang-Hyub Han Objective: this study was to investigate the clinical,virological, and immunological course of acute HBV infection in order to gain more information of HBV infection characteristics responsible for viral clearance or persistence.Methods: A total of 348 patients with acute hepatitis B were prospectively followed up for more than 24 weeks(acute Hepatitis

B with viral persistence for at least 48 weeks), biochemical, virological, and immunological parameters of these patients detected at different time-points of the follow-up were analyzed. Results: Among the 348 acute hepatitis B patients, 286 subjects were NVP-BKM120 male, and the mean age was 35.38±11.46 years. 328 patients resolved HBV spontaneously, selleckchem while the remaining 20 patients developed chronic HBV infection. There were statistically significant differences in age(35.77±11.41 vs29.00±10.62years,P<0.01), peak ALT(1358.62±645.17vs893.64±385.13U/L, P<0.05), serum HBV DNA(2.79±0.05vs8.82±0.40

log10 IU/ml, P<0.01),and the ratio of acute icteric hepatitis (78.45%vs40.00%)between patients who developed spontaneous viral clearance and those who did not. HBV DNA in patients with viral clearance became undetectable accompanied by normalization of alanine aminotransferase levels in 24w; but HBV DNA in the subjects with viral persistence demonstrated persistent viremia and abnormal alanine aminotransferase levels in 80% patients. All these individuals with viral persistence were treated with Peg-interferon antiviral therapy, the serum HBV DNA disappearance was observed in 65 percents at the 24W of follow up, and 50 percents of these patients showed HBsAg serologic loss and HBsAg seroconversion. Intrahepatic total HBV DNA and cccDNA levels at baseline were detectable in 24 patients,who had been identified with spontaneous HBV clearance at 24 weeks follow-up, the results showed there was significant correlation between serum HBV DNA levels with Intrahepatic cccDNA levels(r= 0.608, P<0.05), intrahepatic total HBV DNA also correlated with intrahepatic cccDNA(r=0.739, P< 0.01),but there was no significant correlations with Intrahepatic total HBV DNA levels(r= 0.108, P>0.05).