9 showed a positive correlation between the 25-hydroxyvitamin D concentration and insulin sensitivity, and subjects with hypovitaminosis D were found to be at higher risk for insulin resistance and metabolic syndrome. These findings make it rational for us to infer that the prevalence of vitamin D insufficiency and hypovitaminosis D among African Americans

can increase their risk of insulin resistance. This may account in part for the fact that despite the lower levels of intraperitoneal and liver fat in African Americans, their prevalence of insulin resistance is similar to that of Hispanics, who possess the highest intraperitoneal and liver fat levels.1 Therefore, vitamin D insufficiency www.selleckchem.com/products/Everolimus(RAD001).html and hypovitaminosis D in African Americans may provide useful clues for understanding their high prevalence of insulin resistance. Hong-Fang Ji Ph.D*, * Shandong Provincial

Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, People’s Republic of China. “
“Primary hepatic lymphoma is a rare lymphoma that is confined to the liver with no evidence of involvement of the spleen, lymph nodes, bone marrow or other lymphoid structures. The most common presenting symptom is discomfort or pain in the right upper quadrant of the abdomen. This is sometimes accompanied by malaise, anorexia, weight loss, fever, nausea and vomiting. There are also case reports of fulminant hepatic 上海皓元 failure with hepatic encephalopathy. The

typical radiological appearance is that of BMN 673 nmr a solitary lesion although multiple lesions or diffuse liver infiltration have also been described. In most patients, the differential diagnosis will include primary and secondary hepatic tumors as well as systemic lymphoma with secondary hepatic involvement. Case reports have raised the possibility of an association between primary hepatic lymphoma and hepatitis C but, for most patients, the pathogenesis remains unclear. We describe two patients with primary hepatic, B-cell lymphomas who had negative serological tests for both hepatitis B and C. The first patient was a 92-year-old woman who was admitted to hospital because of epigastric pain, nausea, vomiting, weight loss and fever over the preceding 6 months. Physical examination revealed enlargement of the left lobe of the liver and mild ascites. A contrast-enhanced computed tomography (CT) scan of the abdomen showed multiple hypodense lesions in the left and right lobes of the liver (Figure 1). She also had thrombosis of the inferior vena cava. A liver biopsy under ultrasound control revealed a neoplastic population of intermediate and large lymphoid cells with immunochemical stains that were positive for CD20 and bcl-6. Other investigations including a bone marrow biopsy were normal. She declined therapy and died after 3 months.