This surgical approach is similar, but more risky, than well-established mechanical thrombus retrieval procedure commonly applied in peripheral arteries embolism [12]. We describe two cases of uncommon carotid bifurcation saddle thrombosis of cardiac origin and a case of local thrombosis on a complicated carotid plaque. All these features could be detected easily with ultrasound, leading to the following implicated therapeutical decisions. DR, male, 84 years old, hypertensive, affected by chronic atrial fibrillation, presented acute left hemiplegia. Cerebral CT scan showed an extensive ischemic damage in the right middle cerebral

artery (MCA) territory, with CT hyperdense MCA sign, indicative of intracranial vessel M1 occlusion (Fig. 1A). Carotid duplex (Siemens S2000; 9, 14, 18 MHz linear RO4929097 solubility dmso probes) showed a saddle thrombus at the right carotid bifurcation: the head of the clot was floating in the internal carotid artery and only partially reducing the lumen, and the tail was mobile in the external carotid artery (Fig. 1 C and D, Clip 1). Flow in the distal internal carotid

artery was preserved, with only slight increased resistive indices (Fig. 1D, Clip 2). Even though the mobile clot seemed to be very harmful for the possibility of further distal embolism, considering the MCA occlusion and the extensive ischemic cerebral damage, surgery was however considered not indicated and the patient underwent

only medical treatment. FR, male, 47 years old, asymptomatic for relevant cardiovascular JAK cancer history, presented acute mental confusion and bilateral strength deficit at the lower limbs. Cerebral MRI scan showed an ischemic damage in both the anterior cerebral arteries (ACA) territory. Both ACA were scarcely visible at magnetic resonance angiography while MCAs were patent and the related brain parenchyma spared from ischemic damage (Fig. 2A). Carotid duplex (Siemens S2000; 9, 14, 18 MHz linear probes) showed a clot in the left carotid bulb, adherent to the anterior vessel wall (Fig. 2 B–D, Clip 3). Considering the patency of both the MCAs and that the cerebral tissue was still normal in the left MCA territory, the patient was successfully operated in emergency, Ergoloid to prevent further embolism. A second MRA revealed that both ACAs were originating from the left side, thus explaining why embolism affected the ACA bilaterally from the left bifurcation. Further cardiovascular screening revealed multiple thromboses, at the pulmonary artery and at the saphenofemoral right junction and the patient was also positioned a caval filter. Blood coagulation tests revealed altered AT III, Prot C and Prot S levels. Patient was then treated with anticoagulants. MD, 63 years old, slight hypercholesterolemic, presented acute transient mild left hemiparesis, with rapid spontaneous recovery.